Westmead Millennium Institute logo

 

 

Clinical Associate Professor Philip John O'ConnellClinical Professor Philip O'Connell

Director, Transplantation and CTRR

Philip O'Connell is a Clinical Professor in Medicine. He is Director of the Centre for Transplant and Renal Research and Director of Transplant Medicine and the Clinical Islet Transplant Program at Westmead Hospital.

He gained his medical degree at the University of NSW and undertook a PhD at the University of Melbourne with Professor Tony d'Apice in the department of Professor Kincaid-Smith.

 

He then went on to do Post-doctoral research in transplantation immunology with Professor Terry Strom, Harvard Medical School before returning to Westmead Hospital as a nephrologist.


Research Interests

 

His main research interest is in islet transplantation and he is director of the Australian Clinical Islet Transplant Consortium.

 

His laboratory research is focused primarily on the immunobiology of islet xenograft rejection and developing islet xenografts as a clinical therapy. He is past-director of a joint NHMRC/JDRF program grant that is devoted to the development of pig islets as treatment for Type 1 diabetes.

 

His other focus is the study of kidney graft outcome using new research technologies such as gene-chip microarray technology. This research is funded by the NIH.

 

He has long-standing collaborations with researchers at, Mount Sinai School of Medicine New York, Harvard Medical School, Walter and Eliza Hall Institute, St Vincent's Hospital Melbourne, The Garvan Institute, Adelaide University and The Children's Hospital at Westmead.

 

 

Back to the top

 

Publications

 

- 2009 - 2008 - 2007 - 2006 - 2005 - 2004 - 2003 -

 

2009

  • Akima, S., Hawthorne, W., Favaloro, E., Patel, A., Blyth, K., Mudaliar, Y., Chapman, J., O'Connell, P. Tirofiban and Activated Protein C Synergistically Inhibit the Instant Blood Mediated Inflammatory Reaction (IBMIR) from Allogeneic Islet Cells Exposure to Human Blood. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2009; 9:1533-40. [Abstract]
  • Cross, N., Webster, A., O'Connell, P., Jeoffreys, N., Dwyer, D., Craig, J. Diagnostic accuracy of blood qualitative nucleic acid testing for polyomavirus-associated nephropathy in kidney recipients. Nephrology. 2009; 14:350-356. [Abstract]
  • Cross, N., Webster, A., Masson, P., O'Connell, P., Craig, J. Antihypertensive treatment for kidney transplant recipients. Cochrane Database of Systematic Reviews. 2009; 0:CD003598. [Abstract]

2008

  • Fu, Y., Yi, S., Wu, J., Jimenez, E., Simond, D., Hawthorne, W., O'Connell, P. In vitro suppression of xenoimmune-mediated macrophage activation by human CD4+CD25+ regulatory T cells. Transplantation. 2008; 86:865-874. [Abstract]
  • Feller, J., Simpson, A., Nelson, M., Swan, M., O'Connell, P., Hawthorne, W., Tao, C., O'Brien, B. Growth Promoting Effect of Rh(D) Antibody on Human Pancreatic Islet Cells. The Journal of clinical endocrinology and metabolism. 2008; 93:3560-7. [Abstract]
  • Fu, Y., Lu, X., Yi, S., Wu, J., O'Hara, J., Hawthorne, W., Hucker, K., O'Connell, P. Selective rejection of porcine islet xenografts by macrophages. Xenotransplantation. 2008; 15:307-312. [Abstract]
  • Vitalone, M., O'Connell, P., Jimenez-Vera, E., Yuksel, A., Wavamunno, M., Fung, C., Chapman, J., Nankivell, B. Epithelial-to-Mesenchymal Transition in Early Transplant Tubulointerstitial Damage. Journal of the American Society of Nephrology : JASN. 2008; 19:1571-83. [Abstract]
  • Wu, J., Yi, S., Ouyang, L., Jimenez, E., Simond, D., Wang, W., Wang, Y., Hawthorne, W., O'connell, P. In Vitro Expanded Human CD4+CD25+ Regulatory T Cells are Potent Suppressors of T-Cell-Mediated Xenogeneic Responses. Transplantation. 2008; 85:1841-1848. [Abstract]
  • O'Connell, P. The rationale and practical issues for the maintenance of clean herds for clinical islet xenotransplantation. Xenotransplantation. 2008; 15:91-92. [Abstract]

2007

  • Wavamunno, M., O'connell, P., Vitalone, M., Fung, C., Allen, R., Chapman, J., Nankivell, B. Transplant Glomerulopathy: Ultrastructural Abnormalities Occur Early in Longitudinal Analysis of Protocol Biopsies. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2007; 7:2757-68. [Abstract]
  • Nottle, M., Beebe, L., Harrison, S., McIlfatrick, S., Ashman, R., O'Connell, P., Salvaris, E., Fisicaro, N., Pommey, S., Cowan, P., d'Apice, A. Production of homozygous alpha-1,3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer. Xenotransplantation. 2007; 14:339-344. [Abstract]
  • Lehnert, A., Murray-Segal, L., Cowan, P., d'Apice, A., O'Connell, P. Blockade of the passive cell death pathway does not prevent tolerance induction to islet grafts. Transplantation. 2007; 83:653-655. [Abstract]
  • Yi, S., Wang, Y., Chandra, A., O'Hara, J., Wu, J., Ouyang, L., Burgess, J., Hawthorne, W., Wu, H., Chadban, S., O'Connell, P. Requirement of MyD88 for macrophage-mediated islet xenograft rejection after adoptive transfer. Transplantation. 2007; 83:615-623. [Abstract]
  • Londrigan, S., Brady, J., Sutherland, R., Hawthorne, W., Thomas, H., Jhala, G., Cowan, P., Kay, T., O'Connell, P., Lew, A. Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets. Xenotransplantation. 2007; 14:119-25. [Abstract]
  • Nankivell, B., Wavamunno, M., Borrows, R., Vitalone, M., Fung, C., Allen, R., Chapman, J., O'Connell, P. Mycophenolate mofetil is associated with altered expression of chronic renal transplant histology. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2007; 7:366-376. [Abstract]
  • Chandra, A., Ouyang, L., Yi, S., Wong, J., Ha, H., Walters, S., Patel, A., Stokes, R., Jardine, M., Hawthorne, W., O'Connell, P. Chemokine and toll-like receptor signaling in macrophage mediated islet xenograft rejection. Xenotransplantation. 2007; 14:48-59. [Abstract]

2006

  • Kee, T., Chapman, J., O'Connell, P., Fung, C., Allen, R., Kable, K., Vitalone, M., Nankivell, B. Treatment of Subclinical Rejection Diagnosed by Protocol Biopsy of Kidney Transplants. Transplantation. 2006; 82:36-42. [Abstract]
  • Wavamunno, M., Vitalone, M., Borrows, R., Fung, C., Allen, R., O'Connell, P., Chapman, J., Nankivell, B. Mycophenolate mofetil reduces the histological expression of chronic allograft nephropathy. Immunology and Cell Biology. 2006; 84:A11-A11. [Abstract]
  • Akima, S., Hawthorne, W., Koutts, J., Patel, A., Burgess, J., O'Hara, J., Mudaliar, Y., Favaloro, E., O'Connell, P. Differences in the efficacy of recombinant human activated protein C against allogeneic and xenogeneic IBMIR. Immunology and Cell Biology. 2006; 84:A16-A16. [Abstract]
  • Simond, D., Moran, C., Garkavenko, O., O'Connell, P., Hawthorne, W. Real-time PCR detection of porcine endogenous retroviruses. Immunology and Cell Biology. 2006; 84:A24-A24. [Abstract]
  • Chandra, A., Wong, J., Yi, S., Ha, H., Hawthorne, W., Patel, A., O'Connell, P. Lack of IL-15 reduces recruitment of xenoreactive leukocytes into discordant islet xenografts but does not prolong graft survival. Immunology and Cell Biology. 2006; 84:A8-A9. [Abstrac]
  • Hawthorne, W., Patel, A., O'Hara, J., Burgess, J., Akima, S., Salvaris, E., Favaloro, E., Nottle, M., d'Apice, A., Cowan, P., O'Connell, P. Elimination of the alpha Gal antigen on NICC reduces ibmir following exposure of pig NICC to human blood. Immunology and Cell Biology. 2006; 84:A1-A1. [Abstract]
  • Allen, R., Lau, H., Nankivell, B., O'Connell, P., Lennox, A., Pussell, B., Chapman, J. When all the planets are in alignment. Immunology and Cell Biology. 2006; 84:A22-A22. [Abstract]
  • Robertson, P., Allen, R., O'Connell, P., Pleass, H., Nankivell, B., Waugh, D., Chapman, J. Transplant beta cell function and the 'lazarus factor'. Immunology and Cell Biology. 2006; 84:A10-A10. [Abstract]
  • Goddard, K., Pleass, H., Cross, N., O'Connell, P., Chapman, J., Nankivell, B., Allen, R. A twist of fate or fated to twist?. Immunology and Cell Biology. 2006; 84:A6-A6. [Abstract]
  • Vitalone, M., Kirk, M., Allen, R., Pleass, H., Chapman, J., O'Connell, P., Nankivell, B. Epithelial-to-mesenchymal transition (EMT) in chronic allograft nephropathy (CAN). Immunology and Cell Biology. 2006; 84:A2-A2. [Abstract]
  • Hawthorne, W., Stokes, R., Patel, A., Burgess, J., Walters, S., Simond, D., O'Connell, P. Westran fetal pig pancreas fragment transplants provide long-term normoglycaemia in adult pigs. Immunology and Cell Biology. 2006; 84:A8-A8. [Abstract]
  • O'Connell, P., Hawthorne, W., Holmes-Walker, D., Nankivell, B., Gunton, J., Patel, A., Walters, S., Pleass, H., Allen, R., Chapman, J. Clinical islet transplantation in type 1 diabetes mellitus: results of Australia's first trial. The Medical journal of Australia. 2006; 184:221-5. [Abstract]
  • O'Connell, P., Lew, A., Cowan, P., Londrigan, S., Hawthorne, W., Nottle, M., d'Apice, A. Islet xenotransplantation: progress towards a clinical therapy. Current Opinion in Organ Transplantation. 2006; 11:174-179.

2005

  • Yi, S., Ouyang, L., Ha, H., O'Hara, J., Chandra, A., Akima, S., Hawthorne, W., Patel, A., Stokes, R., O'Connell, P. Involvement of CCR5 signaling in macrophage recruitment to porcine islet xenografts. Transplantation. 2005; 80:1468-75. [Abstract]
  • Chapman, J., O'Connell, P., Nankivell, B. Chronic renal allograft dysfunction. Journal of the American Society of Nephrology: JASN. 2005; 16:3015-26. [Abstract]
  • O'Connell, P. Thrombotic microangiopathy: the next big hurdle for xenotransplantation. Journal of the American Society of Nephrology: JASN. 2005; 16:2529-30. [Abstract]
  • Gunton, J., Kulkarni, R., Yim, S., Okada, T., Hawthorne, W., Tseng, Y., Roberson, R., Ricordi, C., O'Connell, P., Gonzalez, F., Kahn, C. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell. 2005; 122:337-49. [Abstract]
  • Vitalone, M., Nankivell, B., Kirk, M., Allen, R., Pleass, H., Lau, H., Chapman, J., O''Connell, P. The use of gene arrays to study the pathogenesis of chronic allograft nephropathy (CAN). Immunology and Cell Biology. 2005; 83:A26-A26. [Abstract]
  • Wong, K., Kable, K., Hawthorne, W., Robertson, P., Chan, K., Nankivell, B., O''Connell, P., Chapman, J., Lau, H., Pleass, H., Allen, R. A comparison of 2 surgical techniques in pancreas transplantation. Immunology and Cell Biology. 2005; 83:A23-A24. [Abstract]
  • Wavamunno, M., Nankivell, B., Chapman, J., Kable, K., Allen, R., Pleass, H., O''Connell, P. The impact of screening for BK virus in renal allograft recipients. Immunology and Cell Biology. 2005; 83:A15-A16. [Abstract]
  • Lee, J., Simond, D., Hawthorne, W., Walters, S., Patel, A., Smith, D., O'Connell, P., Moran, C. Characterization of the swine major histocompatibility complex alleles at eight loci in Westran pigs. Xenotransplantation. 2005; 12:303-7. [Abstract]
  • Mysore, T., Shinkel, T., Collins, J., Salvaris, E., Fisicaro, N., Murray-Segal, L., Johnson, L., Lepore, D., Walters, S., Stokes, R., Chandra, A., O'Connell, P., d'Apice, A., Cowan, P. Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function. Diabetes. 2005; 54:2109-16. [Abstract]
  • Wilkinson, A., Davidson, J., Dotta, F., Home, P., Keown, P., Kiberd, B., Jardine, A., Levitt, N., Marchetti, P., Markell, M., Naicker, S., O'Connell, P., Schnitzler, M., Standl, E., Torregosa, J., Uchida, K., Valantine, H., Villamil, F., Vincenti, F., Wissing, M. Guidelines for the treatment and management of new-onset diabetes after transplantation. Clinical transplantation. 2005; 19:291-8. [Abstract]

2004

  • Nankivell, B., Borrows, R., Fung, C., O'Connell, P., Chapman, J., Allen, R. Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology. Transplantation. 2004; 78:557-65. [Abstract]
  • Nankivell, B., Borrows, R., Fung, C., O'Connell, P., Allen, R., Chapman, J. Evolution and pathophysiology of renal-transplant glomerulosclerosis. Transplantation. 2004; 78:461-8. [Abstract]
  • Nankivell, B., Borrows, R., Fung, C., O'Connell, P., Chapman, J., Allen, R. Delta analysis of posttransplantation tubulointerstitial damage. Transplantation. 2004; 78:434-41. [Abstract]
  • Nankivell, B., Borrows, R., Fung, C., O'Connell, P., Allen, R., Chapman, J. Natural history, risk factors, and impact of subclinical rejection in kidney transplantation. Transplantation. 2004; 78:242-9. [Abstract]
  • Chandra, A., Salvaris, E., Walters, S., Murray-Segal, L., Gock, H., Lehnert, A., Wong, J., Cowan, P., d'Apice, A., O'Connell, P. Fate of alphaGal +/+ pancreatic islet grafts after transplantation into alphaGal knockout mice. Xenotransplantation. 2004; 11:323-31. [Abstract]
  • Zhan, Y., Brown, L., Deliyannis, G., Seah, S., Wijburg, O., Price, J., Strugnell, R., O'Connell, P., Lew, A. Responses against complex antigens in various models of CD4 T-cell deficiency: surprises from an anti-CD4 antibody transgenic mouse. Immunologic research. 2004; 30:1-14. [Abstract]

2003

  • Nankivell, B., Borrows, R., Fung, C., O'Connell, P., Allen, R., Chapman, J. The natural history of chronic allograft nephropathy. The New England journal of medicine. 2003; 349:2326-33. [Abstract]
  • Yi, S., Hawthorne, W., Lehnert, A., Ha, H., Wong, J., van Rooijen, N., Davey, K., Patel, A., Walters, S., Chandra, A., O'Connell, P. T cell-activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts. Journal of immunology (Baltimore, Md. : 1950). 2003; 170:2750-8. [Abstract]
  • Russ, G., Campbell, S., Chadban, S., Eris, J., O'connell, P., Pussell, B., Walker, R. Reduced and standard target concentration tacrolimus with sirolimus in renal allograft recipients. Transplantation Proceedings. 2003; 35 (Suppl 3):115S-117S.

 

Back to the top

 

Contact Details

T +61 2 9845 6962

F +61 2 9633 9351

E philip_oconnell@wsahs.nsw.gov.au

 

Back to the top

 

 

 

 

 

 

 

 

| Home | About Us | Research | Our People | Westmead Medical Research Foundation | News & Events | Contact Us | Search |

 

© 2000-2008 Westmead Millennium Institute