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Associate Professor Graham MannAssociate Professor Graham Mann

Melanoma Genomics and Genetic Epidemiology Research Group

Graham Mann is an Associate Professor in Medicine at the University of Sydney. After training in medical oncology at Royal Prince Alfred Hospital, Sydney, he worked as a graduate student at the Ludwig Institute for Cancer Research, Sydney Branch, and at the University of Umeå, Sweden, before moving to Westmead in 1990 to work in human genetics as a full-time researcher. He is a founding and Executive member of the Kathleen Cuningham Consortium for research in familial breast cancer (kConFab), and chairs its Data and Analysis Subcommittee.

 

He is a founding member and principal investigator of the international Melanoma Genetics Consortium. He has been an office-bearer and President (1996) of the Australian Society for Medical Research, and serves on the Membership Committee of the international Melanoma Research Society. He helps lead research programs of NHMRC and the Cancer Institute NSW focussed on melanoma.

 

He chaired NHMRC Grant Review Panels in Genetics in 2001-2002, and a principal curriculum subcommittee (Basic and Clinical Sciences Theme) of the University of Sydney Medical Program in 2004-7 He is an elected member of the Management Committee of the University of Sydney Cancer Research Network, and was recently appointed as an Associate Dean (Research) in the Faculty of Medicine. He is a member of the Board of Directors of the Cancer Council NSW (2006-) and of its Cancer Research and Governance Committees. He directs the Westmead Singers and performs with the Spooky Men's Chorale.

Research Interests

Genetic and environmental causes of:

  • melanoma
  • breast cancer
  • non-melanoma skin cancer
  • prostate cancer.

Click here for information on Westmead Institute for Cancer Research.

 

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Projects

 

Click here for more Information including newsletters and forms for the following projects:

  • Genetic Epidemiology of Melanoma (GenoMEL)
  • Genetic Susceptibility of Non-Melanoma Skin Cancer
  • Australian Melanoma Family Study.

 

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Publications

- 2009 - 2008 - 2007 - 2006 -2005 - 2004 -2003 - 2002 -2001 -2000 -

 

2009

  • Becker TM, Haferkamp S, Dijkstra MK, Scurr LL, Frausto M, Diefenbach E, Scolyer RA, Reisman DN, Mann GJ, Kefford RF, Rizos H (2009) The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a. Mol Cancer 8: 4 [Abstract]

  • Bishop DT, Demenais F, Iles MM, Harland M, Taylor JC, Corda E, Randerson-Moor J, Aitken JF, Avril MF, Azizi E, Bakker B, Bianchi-Scarra G, Bressac-de Paillerets B, Calista D, Cannon-Albright LA, Chin AWT, Debniak T, Galore-Haskel G, Ghiorzo P, Gut I, Hansson J, Hocevar M, Hoiom V, Hopper JL, Ingvar C, Kanetsky PA, Kefford RF, Landi MT, Lang J, Lubinski J, Mackie R, Malvehy J, Mann GJ, Martin NG, Montgomery GW, van Nieuwpoort FA, Novakovic S, Olsson H, Puig S, Weiss M, van Workum W, Zelenika D, Brown KM, Goldstein AM, Gillanders EM, Boland A, Galan P, Elder DE, Gruis NA, Hayward NK, Lathrop GM, Barrett JH, Bishop JA (2009) Genome-wide association study identifies three loci associated with melanoma risk. Nat Genet 41: 920-925 [Abstract]

  • Gartside MG, Chen H, Ibrahimi OA, Byron SA, Curtis AV, Wellens CL, Bengston A, Yudt LM, Eliseenkova AV, Ma J, Curtin JA, Hyder P, Harper UL, Riedesel E, Mann GJ, Trent JM, Bastian BC, Meltzer PS, Mohammadi M, Pollock PM (2009) Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma. Mol Cancer Res 7: 41-54 [Abstract]

  • Kasparian NA, Meiser B, Butow PN, Simpson JM, Mann GJ (2009) Genetic testing for melanoma risk: a prospective cohort study of uptake and outcomes among Australian families. Genetics in Medicine 11: 265-278 [Abstract]

  • Leachman SA, Carucci J, Kohlmann W, Banks KC, Asgari MM, Bergman W, Bianchi-Scarra G, Brentnall T, Bressac-de Paillerets B, Bruno W, Curiel-Lewandrowski C, de Snoo FA, Debniak T, Demierre MF, Elder D, Goldstein AM, Grant-Kels J, Halpern AC, Ingvar C, Kefford RF, Lang J, MacKie RM, Mann GJ, Mueller K, Newton-Bishop J, Olsson H, Petersen GM, Puig S, Rigel D, Swetter SM, Tucker MA, Yakobson E, Zitelli JA, Tsao H (2009) Selection criteria for genetic assessment of patients with familial melanoma. J Am Acad Dermatol 61: 677 e1-14 [Abstract]

  • Morey AL, Murali R, McCarthy SW, Mann GJ, Scolyer RA (2009) Diagnosis of cutaneous melanocytic tumours by four-colour fluorescence in situ hybridisation. Pathology 41: 383-387 [Abstract]

 

2008

  • Kasparian, N.A., Meiser, B., Butow, P.N., Simpson, J.M., Mann, G.J.. Predictors of psychological distress among individuals with a strong family history of malignant melanoma. Clinical Genetics 73(2): 121-131 (2008). [Abstract]
  • Wakefield, C.E., Meiser, B., Gaff, C.L., Barratt, A., Patel, M.I., Suthers, G., Lobb, E.A., Ramsay, J., Mann G.J. A multidisciplinary overview of the issues faced by unaffected men with a family history of prostate cancer. Journal of Urology (accepted December 19, 2007). [Abstract]
  • Harland, M., Goldstein, A.M., Kukalizch, K., Taylor, C., Hogg, D., Puig, S., Badenas, C., Gruis, N., ter Huurne, J., Bergman, W., Hayward, N.K., Stark, M., Tsao, H., Tucker, M.A., Landi, M.T., Bianchi Scarrà, G., Ghiorzo, P., Kanetsky, P.A., Elder, D., Mann, G.J., Holland, E.A, Bishop, D.T., Newton Bishop, J. A comparison of CDKN2A mutation detection within the Melanoma Genetics Consortium (GenoMEL) European Journal of Cancer (accepted March 7, 2008). [Abstract]
  • Brown, K.M., MacGregor, S., Montgomery, G., Craig, D.W., Zhao, Z.Z., Iyadurai, K., Henders, A., Homer, N., Campbell, M., Stark, M., Thomas, S., Schmid, H, Holland, E.A., Gillanders, E.M., Duffy, D.L., Maskiell, J.A., Jetann, J., Ferguson, M., Stephan, D.A., Cust, A.E., Whiteman, D., Green, A., Olsson, H., Puig, S., Ghiorzo, P., Hansson, J., Demenais, F., Goldstein, A.M., Gruis, N.A., Elder, D.E., Newton Bishop, J., Kefford, R.F., Giles, G.G., Armstrong, B.K., Aitken, J.F., Hopper, J.L., Martin, N.G., Trent, J.M., Mann, G.J., Hayward, N.K. Common sequence variants on 20q11.22 confer melanoma susceptibility. Nature Genetics (accepted 16 Apr 2008) [Abstract]

2007

  • Kasparian, N.A., Meiser, B., Butow, P.N., Job, R.F.S., Mann, G.J. Anticipated uptake of genetic testing for familial melanoma in an Australian sample: an exploratory study. Psycho-Oncology 16: 69-78 (2007). [Abstract]
  • Indsto, J.O., Kumar, S., Wang, L., Crotty, K.A., Mann, G.J. Low prevalence of RAS-RAF activating mutations in Spitz melanocytic naevi compared with other melanocytic lesions. Journal of Cutaneous Pathology 34(6): 448-455 (2007). [Abstract]
  • Goldstein, A.M., Chan, M., Harland, M., Hayward, N.K., Demenais, F., Bishop, D.T., Azizi, E., Bergman, W., Bianchi-Scarra, G., Bruno, W., Calista, D., Cannon Albright, L.A., Chaudru, V., Chompret, A., Cuellar, F., Elder, D.E., Ghiorzo, P., Gillanders, E.M., Gruis, N.A., Hansson, J., Hogg, D., Holland, E.A., Kanetsky, P.A., Kefford, R.F., Landi, M.T., Lang, J., Leachman, S.A., MacKie, R.M., Magnusson, V., Mann, G.J., Newton Bishop, J., Palmer, J.M., Puig, S., Puig-Butille, J.A., Stark, M., Tsao, H., Tucker, M.A., Whitaker, L., Yakobson, E., The Lund Melanoma Study Group, The Melanoma Genetics Consortium (GenoMEL). Features associated with germline CDKN2A mutations: A GenoMEL study of melanoma-prone families from three continents. Journal of Medical Genetics 44: 99-106 (2007). [Abstract]
  • Kasparian, N.A., Butow, P.N., Meiser, B., Mann, G.J. High- and average-risk individuals’ beliefs about, and perceptions of, malignant melanoma: an Australian perspective. Psycho-Oncology (accepted April 20, 2007) [Abstract]
  • Gurney, H., Wong, M., Balleine, R.L., Rivory, L.P., McLachlan, A.J., Hoskins, J.M., Wilcken, N., Clarke, C.L., Mann, G.J., Collins, M., Delforce, S.-E., Lynch, K., Schran, H. Imatinib Disposition and ABCB1 (MDR1, P-Glycoprotein) Genotype. Clinical Pharmacology and Therapeutics 82(1): 33-40 (2007)  [Abstract]
  • Lose, F., Arnold, J., Young, D., Brown, C.J., Mann, G.J., Pupo. G.M., kConFab, Khanna, K.K., Chenevix-Trench, G., Spurdle, A.B. BCoR-L1 variation and breast cancer. Breast Cancer Research 9(4): R54 [Epub ahead of print] (2007)
  • Wong, E.E.M., Tesoriero, A.A., Pupo, G.M., kConFab, ABCFS, McCredie, M.R.E., Giles, G.G., Mann, G.J., Goldgar, D.E., Southey, M.C., Hopper, J.L. Is MSH2 a breast cancer susceptibility gene. Familial Cancer (accepted September 21, 2007) [Abstract]

2006

  • Wong, M., Balleine, R.L., Blair, E.Y.L., McLachlan, A.J., Ackland, S.P., Garg, M.B., Evans, S., Farlow, D., Collins, M., Rivory, L.P., Hoskins, J.M., Mann, G.J., Clarke, C.L.Gurney, H. Predictors of vinorelbine pharmacokinetics and pharmacodynamics in patients with cancer. Journal of Clinical Oncology 24(16): 2448-55 (2006). [Abstract]
  • Mann, G.J., Thorne, H., Balleine, R.L., Butow, P.N., Clarke, C.L., Edkins, E., Evans, G.M., Fereday, S., Haan, E., Gattas, M., Giles, G.G., Goldblatt J., Hopper, J.L., Kirk, J., Leary, J.A., Lindeman, G., Niedermayr, E., Phillips, K.-A., Picken, S., Pupo, G.M., Saunders, C., Scott, C.L., Spurdle, A.B., Suthers, G., Tucker, K., Chenevix-Trench, G., for The Kathleen Cuningham Consortium for Research in Familial Breast Cancer. Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource. Breast Cancer Research 8(1): R12 (Epub Feb 13, 2006). [Abstract]
  • Smith, P., McGuffog, L., Easton, D.F., Mann, G.J., Pupo, G.M., Newman, B., Chenevix-Trench, G., kConFab Investigators, Szabo, C., Southey, M., Renard, H., Odefrey, F., Lynch, H., Stoppa-Lyonnet, D., Couch, F., Hopper, J.L., Buys, S., Andrulis, I., Senie, R., BCFS, BRCAX Collaborators group, Goldgar, D.E., Oldenburg, R., Kroeze-Jansema, K., Kraan, J., Meijers-Heijboer, H., Klijn, J.G.M., van Asperen, C., van Leeuwen, I., Vasen, H.F.A, Cornelisse, C.J., Devilee, P., Baskcomb, L., Seal, S., Barfoot, R., Mangion, J., Hall, A., Edkins, S., Rapley, E., Wooster, R., Chang-Claude, J., Eccles, D., Evans, D.G., Futreal, P.A., Nathanson, K.L., Weber, B.L., the Breast Cancer Susceptibility Collaboration (UK), Rahman, N., Stratton, M.R.. A genome wide linkage search for breast cancer susceptibility genes. Genes, Chromosomes and Cancer 45(7): 646-655 (2006). [Abstract]
  • Kasparian, N.A., Meiser, B., Butow, P.N., Job, R.F.S., Mann, G.J. Better the devil you know? A qualitative analysis of high risk individuals’ anticipated psychological responses to genetic testing for melanoma susceptibility. Journal of Genetic Counselling 15(6): 433-447 (2006).  [Abstract]
  • Lose, F., Chenevix-Trench G., Mann, G.J., Pupo G.M., kConFab investigators, Spurdle, A.B. Variation in the RAD51 gene and familial breast cancer. Breast Cancer Research 8(3): R26 (Epub Jun 8, 2006).  [Abstract]
  • Goldstein, A.M., Chan, M., Harland, M., Gillanders, E.M., Hayward, N.K., Avril, M.-F., Azizi, E., Bianchi-Scarra, G., Bressac-de Paillerets, B., Bruno, W., Calista, D., Cannon Albright, L.A., Demenais, F., Elder, D.E., Ghiorzo, P., Gruis, N.A., Hansson, J., Hogg, D., Holland, E.A., Kanetsky, P.A., Kefford, R.F., Landi, M.T., Lang, J., Leachman, S.A., MacKie, R.M., Magnusson, V., Mann, G.J., Niendorf, K., Newton Bishop, J., Palmer, J.M., Puig, S., Puig-Butille, J.A., de Snoo, F.A., Stark, M.A., Tsao, H., Tucker, M.A., Whitaker, L., Yakobson, E., The Lund Melanoma Study Group, and the Melanoma Genetics Consortium (GenoMEL). Assessment of high-risk melanoma susceptibility genes and their associations with pancreatic cancer, neural system tumors, and uveal melanoma: a Melanoma Genetics Consortium (GenoMEL) study. Cancer Research 66(20): 9818-9828 (2006). [Abstract]
  • Marsh, A., Healey, S., Lewis, A., Spurdle, A.B., Kedda, M.A., Khanna, K.K., kConFab, Mann, G.J., Pupo, G.M., Lakhani, S.R., Chenevix-Trench, G. Mutation analysis of five candidate genes in familial breast cancer. Breast Cancer Research and Treatment Dec 23; [Epub ahead of print] (2006). [Abstract]

2005

  • Becker, T, Ayub, A, Kefford, R, Mann, G, Rizos, H. The melanoma-associated 24 base pair duplication in p16INK4a is functionally impaired. International journal of cancer. Journal international du cancer. 2005; 117:569-73 [Abstract]

  • Becker, T, Rizos, H, de la Pena, A, Leclercq, I, Woodruff, S, Kefford, R, Mann, G. Impaired inhibition of NF-kappaB activity by melanoma-associated p16INK4a mutations. Biochemical and biophysical research communications. 2005; 332:873-9 [Abstract]

  • Harland, M, Taylor, C, Bass, S, Churchman, M, Randerson-Moor, J, Holland, E, Mann, G, Bishop, D, Bishop, J. Intronic sequence variants of the CDKN2A gene in melanoma pedigrees. Genes Chromosomes & Cancer. 2005; 43:128-136 [Abstract]

  • Wong, M, Evans, S, Rivory, L, Hoskins, J, Mann, G, Farlow, D, Clarke, C, Balleine, R, Gurney, H. Hepatic technetium Tc 99m-labeled sestamibi elimination rate and ABCB1 (MDR1) genotype as indicators of ABCB1 (P-glycoprotein) activity in patients with cancer. Clinical pharmacology and therapeutics. 2005; 77:33-42

  • Lewis, A, Flanagan, J, Marsh, A, Pupo, G, Mann, G, Spurdle, A, Lindeman, G, Visvader, J, Brown, M, Chenevix-Trench, G, , K. Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer. Breast cancer research: BCR. 2005; 7:R1005-16 [Abstract]

2004

  • Walker, G, Indsto, J, Sood, R, Faruque, M, Hu, P, Pollock, P, Duray, P, Holland, E, Brown, K, Kefford, R, Trent, J, Mann, G, Hayward, N. Deletion mapping suggests that the 1p22 melanoma susceptibility gene is a tumor suppressor localized to a 9-Mb interval. Genes, chromosomes & cancer. 2004; 41:56-64 [Abstract]

2003

  • Clancy, J, Mann, G, 17 Researchers from, P. EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer. Oncogene. 2003; 22:5070-5081

  • Gillanders, E, Holland, E, Kefford, R, Mann, G, 26 Researchers from, P. Localization of a novel melanoma susceptibility locus to 1p22. American Journal Of Human Genetics. 2003; 73:301-313

  • Camp, E, Badhwar, P, Mann, G, Lardelli, M. Expression analysis of a tyrosinase promoter sequence in zebrafish. Pigment Cell Research. 2003; 16:117-126

  • Indsto, J, Nassif, N, Kefford, R, Mann, G. Frequent loss of heterozygosity targeting the inactive X chromosome in melanoma. Clinical Cancer Research. 2003; 9:6476-6482

  • Kefford, R, Mann, G. Is there a role for genetic testing in patients with melanoma?. Current Opinion In Oncology. 2003; 15:157-161

  • Hornbuckle, J, Culjak, G, Jarvis, E, Gebski, V, Coates, A, Mann, G, Kefford, R. Patterns of metastases in familial and non-familial melanoma. Melanoma Research. 2003; 13:1-5

2002

  • Chenevix-Trench, G, Spurdle, A, Gatei, M, Kelly, H, Marsh, A, Chen, X, Donn, K, Cummings, M, Nyholt, D, Jenkins, M, Scott, C, Pupo, G, D?rk, T, Bendix, R, Kirk, J, Tucker, K, McCredie, M, Hopper, J, Sambrook, J, Mann, G, Khanna, K. Dominant Negative ATM Mutations in Breast Cancer Families. Journal Of The National Cancer Institute. 2002; 94:205-215

  • Fung, D, Holland, E, Becker, T, Hayward, N, Bressac-de Paillerets, B, Genetics Consortium, M, Mann, G. EMelanoBase: An Online Locus-Specific Variant Database for Familial Melanoma. Human Mutation. 2002; 21:2-7

  • Bishop, D, Demenais, F, Goldstein, A, Bergman, W, Bishop, J, Bressac-de Paillerets, B, Chompret, A, Ghiorzo, P, Gruis, N, Hassan, J, Harland, M, Hayward, N, Holland, E, Mann, G, Mantelli, M, Nancarrow, D, Platz, A, Tucker, M, Genetics Consortium, M. Geographical Variation in the Penetrance of CDKN2A Mutations for Melanoma. Journal Of The National Cancer Institute. 2002; 94:894-903

2001

  • Becker, T, Rizos, H, Kefford, R, Mann, G. Functional Impairment of Melanoma-associated p16 INK4a mutants in melanoma cells despite retention of cyclin-dependent kinase 4 binding1. Clinical Cancer Research. 2001; 32:449-453

  • Rizos, H, Darmanian, A, Holland, E, Mann, G, Kefford, R. Mutations in the INK4a/ARF Melanoma Susceptibility locus functionally impair p14ARF. Journal of Biological Chemistry. 2001; 29:339-348

  • Marsh, A, Spurdle, A, Turner, B, Fereday, S, Thorne, H, Pupo, G, Mann, G, Hopper, J, Sambrook, J, Chenevix-Trench, G, Australian Breast Cancer Family Study, A, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, K. The intronic G13964C variant in p53 is not a high-risk mutation in familial breast cancer in Australia. Breast Cancer Research. 2001; 61:4576-4582

  • Indsto, J, Cachia, A, Kefford, R, Mann, G. X inactivation, DNA deletion, and microsatellite instability in common acquired melanocytic Nevi1. Clinical Cancer Research. 2001; 8:225-230

2000

  • Cachia, A, Indsto, J, McLaren, K, Mann, G. CDKN2A mutation and deletion status in thin and thick primary melanoma. Clinical Cancer Research. 2000; 6:3511-3515

  • Harland, M, Holland, E, Ghiorzo, P, Mantelli, M, Bianchi-Scarra, G, Goldstein, A, Tucker, M, Ponder, B, Mann, G, Timothy Bishop, D, Newton Bishop, J. Mutation screening of the CDKN2A promoter in melanoma families. Genes, Chromosomes & Cancer. 2000; 28:45-57

  • Rizos, H, Darmanian, A, Mann, G, Kefford, R. Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization. Oncogene. 2000; 19:2978-2985

 

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Contact Details

T +61 2 9845 9056

F +61 2 9845 9102

E gmann@mail.usyd.edu.au

 

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