Dr deFazio has a long-standing commitment to translational research with an emphasis on gynaecological malignancies. Her research program is focused on improving treatment outcome, particularly for women with ovarian cancer, and on identifying factors that modify risk of developing cancer.
She works with a team of postdoctoral researchers, postgraduate students, research assistants and clinical colleagues, and has active collaborations with other local, national and international research groups. The group is supported by national and international peer-reviewed grants.
Dr deFazio is on the management committee of the Australian Ovarian Cancer Study (AOCS), a national molecular epidemiology study on ovarian cancer, in collaboration with colleagues at the Peter MacCallum Cancer Centre and the Queensland Institute for Medical Research, and is the head of the AOCS Clinical Follow-up Core. She is also a chief investigator for the Australasian Biospecimens Network (ABN-Oncology).
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Dr Graham Jones holds a BSc (Hons) University of Sydney, 1986 and PhD University of Sydney, 1991.
Post-doctoral experience at the University of Basel, Switzerland (1992-1998). Research during this time was focussed on the activation of cell surface receptor tyrosine kinases by the extracellular matrix and the regulation of gene transcription by these receptors. This theme was continued during his time at the University Hospital (1998-2001), Basel, and also included the study of human genetics in disease.
Graham's research program has continued to integrate human genetics with cellular and molecular biology, focussing on the immune system.
Genetic association studies of children with severe atopic dermatitis have identified several genes encoding cell surface receptors and nuclear transcription factors.
Work is now well advanced on understanding how heritable polymorphisms in these genes lead to changes in gene or protein function. |
WMI Research Supervisors
Contact List 2010-2011
